Remote effects and thresholds of CBF and CMRO/sub 2/ in MCA territory ischemic infarction with a high resolution positron CT (HEADTOME-III) and 0-15 labeled gases
Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO/sub 2/) were measured with a high resolution positron CT (HEADTOME-III) and 0-15 labeled CO/sub 2/, O/sub 2/ and CO gases. Seven normal volunteers and 13 cases with MCA territory ischemic infarction were performed on positron CT measurement. Remote effects from MCA territory infarction were noted in the following areas without structural damages by X-ray CT and cerebral angiography: (1) contralateral MCA territory, (2) ipsilateral thalamus, (3) contralateral cerebellar hemisphere, and (4) brainstem. Areas shown as remote effects had normal regional oxygen extraction fraction (rOEF), slightly depressed rCBF and rCMRO/sub 2/. These remote effects were demonstrated typically between 1 and 4 weeks after onset. The morphological damages were assessed as low density are with X-ray CT, and threshold levels of rCBF and rCMRo/sub 2/ were determined. Threshold of rCBF was about 12 ml/100 ml/min, and rCMRO/sub 2/ threshold was about 1.4 ml/100 ml/min in acute stroke within 1 day after onset. The areas of remote effects were indicated above these threshold values. These results suggest that (1) remote effects were not ischemic changes, (2) almost cases with MCA territory infarct showed in this effect, (3) these effects very frequently appeared in 1-4 weeks after onsets, (4) these remote effects may have connection of neural tracts, and the areas shown in remote effects may be a ''resting state''.
- Research Organization:
- Research Institute for Brain and Blood Vessels-Akita, Akita
- OSTI ID:
- 6795429
- Report Number(s):
- CONF-850611-; TRN: 87-010650
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CEREBRUM
BLOOD FLOW
METABOLISM
MORPHOLOGICAL CHANGES
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
CARBON DIOXIDE
CARBON MONOXIDE
CEREBRAL CORTEX
ISCHEMIA
LABELLING
OXYGEN 15
PATIENTS
RESOLUTION
TISSUE DISTRIBUTION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques