Remote effects and thresholds of CBF and CMRO/sub 2/ in MCA territory ischemic infarction with a high resolution positron CT (HEADTOME-III) and 0-15 labeled gases

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6795429

Shishido, F; Uemura, K; Inugami, A; Ogawa, T; Yamaguchi, T; Kanno, I; Miura, S; Murakami, M; Takahashi, K; Sasaki, H

Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO/sub 2/) were measured with a high resolution positron CT (HEADTOME-III) and 0-15 labeled CO/sub 2/, O/sub 2/ and CO gases. Seven normal volunteers and 13 cases with MCA territory ischemic infarction were performed on positron CT measurement. Remote effects from MCA territory infarction were noted in the following areas without structural damages by X-ray CT and cerebral angiography: (1) contralateral MCA territory, (2) ipsilateral thalamus, (3) contralateral cerebellar hemisphere, and (4) brainstem. Areas shown as remote effects had normal regional oxygen extraction fraction (rOEF), slightly depressed rCBF and rCMRO/sub 2/. These remote effects were demonstrated typically between 1 and 4 weeks after onset. The morphological damages were assessed as low density are with X-ray CT, and threshold levels of rCBF and rCMRo/sub 2/ were determined. Threshold of rCBF was about 12 ml/100 ml/min, and rCMRO/sub 2/ threshold was about 1.4 ml/100 ml/min in acute stroke within 1 day after onset. The areas of remote effects were indicated above these threshold values. These results suggest that (1) remote effects were not ischemic changes, (2) almost cases with MCA territory infarct showed in this effect, (3) these effects very frequently appeared in 1-4 weeks after onsets, (4) these remote effects may have connection of neural tracts, and the areas shown in remote effects may be a ''resting state''.

• Research Organization: Research Institute for Brain and Blood Vessels-Akita, Akita
• OSTI ID: 6795429
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON MONOXIDE
CARBON OXIDES
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISCHEMIA
ISOTOPES
LABELLING
LIGHT NUCLEI
METABOLISM
MINUTES LIVING RADIOISOTOPES
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXIDES
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PATHOLOGICAL CHANGES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RESOLUTION
TISSUE DISTRIBUTION
TOMOGRAPHY
VASCULAR DISEASES