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Regional cerebral blood flow measured by the gamma camera after direct injection of /sup 133/Xe into the distal stump of the occluded middle cerebral artery

Journal Article · · Stroke; (United States)
OSTI ID:7363245
; ; ; ; ; ; ;
Regional cerebral blood flow (rCBF) was measured after intracarotid injection of /sup 133/Xe concurrently with measurements of local cerebral blood flow (LCBF) after injection of /sup 133/Xe directly into the distal stump of the occluded middle cerebral artery (MCA) by the use of the gamma camera after producing experimental ischemia in baboons by occluding the MCA. Regional MCA stump pressure (rMCAP) was also measured. Regions of ishcemia assessed by intracarotid injection of /sup 133/Xe correlated well with the territory of infarct defined by injection of /sup 133/Xe into the distal MCA stump. Flow values in ischemic regions obtained by direct injection of /sup 133/Xe into the MCA were 15 to 20 percent lower than those obtained by intracarotid injection of /sup 133/Xe. Possible explanations for these differences are discussed. During induced hypertension autoregulation in ischemic areas was abolished and paradoxical responses of LCBF and rMCAP to changes in arterial carbon dioxide tension (Pa/sub CO/sub 2//) were confirmed. (auth)
Research Organization:
Baylor Coll. of Medicine, Houston, TX
OSTI ID:
7363245
Journal Information:
Stroke; (United States), Journal Name: Stroke; (United States) Vol. 6:4; ISSN SJCCA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANEMIAS
ANIMALS
APES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CAMERAS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
EVEN-ODD NUCLEI
GAMMA CAMERAS
HEMIC DISEASES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEASURING METHODS
NERVOUS SYSTEM
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
SYMPTOMS
USES
VERTEBRATES
XENON 133
XENON ISOTOPES