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Effect of small deep hemispheric infarction on the ipsilateral cortical blood flow in man

Journal Article · · Stroke; (United States)
; ; ; ; ; ; ; ;
The effect of small, deep ischemic lesions on the ipsilateral cortical circulation was investigated in 10 patients with persistent mild or moderate neurological deficits due to infarcts in the internal capsule. rCBF studies by the /sup 133/Xe intracarotid injection method were performed 14-180 days after the onset of the infarction. The rCBF functional image was made up from the data of /sup 133/Xe dynamic images measured by an Anger-type gamma camera and the rCBF values were calculated by the initial slope method. The average value of mean rCBFs (mCBF) in 10 patients was 44.9 +/- 7.1 ml/100g/min (average PaCO/sub 2/; 39.9 +/- 4.3 mm Hg). In the rCBF functional images, a focal hypoperfusion area was observed in all cases and localized around the central sulcus, especially in the precentral and central areas. Significant decreases of mCBF and the tendency to decrease of the rCBFs in the hypoperfusion focus were noted in the patients with the larger infarcts in comparison with those with the smaller ones. These results suggest that a small, deep ischemic lesion such as a capsular infarct may have remote effects on the ipsilateral cortical circulation, due probably to the damage of a number of fibers passing through the lesion.
Research Organization:
Kobe Ekisaikai Hospital, Japan
OSTI ID:
5555357
Journal Information:
Stroke; (United States), Journal Name: Stroke; (United States) Vol. 16:1; ISSN SJCCA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
BRAIN
CAMERAS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
GAMMA CAMERAS
IMAGES
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NERVOUS SYSTEM
NUCLEI
ORGANS
PATIENTS
PERFUSED TISSUES
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TISSUES
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES
XENON 133
XENON ISOTOPES