Total lymphoid irradiation in rat heart albgrafts: dose, fractionation, and combination with cyclosporin-A. [X-ray]

Conference · Sun Mar 01 00:00:00 EST 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:6792656

Rynasiewicz, J J; Sutherland, D E.R.; Kawahara, K; Kim, T; Najarian, J S

The survival or organ allografts is prolonged in mice and rats treated with fractionated, high-dose total lymphoid irradiation (TLI). We have studied the effect of TLI, alone or in combination with donor bone marrow or pharmacologic immunosuppression (cyclosporin-A: CY-A), on the survival of heterotopic rat heart allografts. Specifically, we evaluated the generalized immunosuppressive effect of TLI as a function of accumulated dose and fractionation schedule. In addition, TLI and CY-A were used individually in schedules that by themselves gave only moderate graft prolongation and then subsequently in sequential combination.

• Research Organization: Univ. of Minnesota Health Sciences Center, Minneapolis
• OSTI ID: 6792656
• Journal Information: Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FRACTIONATED IRRADIATION
EVALUATION
GRAFTS
BIOLOGICAL RADIATION EFFECTS
HEART
IMMUNOSUPPRESSION
RADIOINDUCTION
IMMUNOSUPPRESSIVE DRUGS
RADIATION DOSES
X RADIATION
DOSE-RESPONSE RELATIONSHIPS
BONE MARROW CELLS
LYMPH NODES
PARTIAL BODY IRRADIATION
RATS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
TRANSPLANTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals