Radiation pneumonitis and fibrosis in mouse lung assayed by respiratory frequency and histology

Journal Article · Wed Oct 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575224· OSTI ID:6792071

Travis, E L; Down, J D; Holmes, S J; Hobson, B

The response of mouse lung to radiation was assessed by measuring breathing frequency up to 52 weeks after graded single doses of x rays to both lungs. Breathing frequency was increased after both lethal and sublethal doses, with damage appearing sooner after higher doses. Dose-response curves were obtained after 14 weeks with a threshold of 12 Gy. All mice given doses greater than 15 Gy died by 22 weeks. Some return of function was observed in the lower dose groups by 36 weeks, but breathing frequency remained elevated for 52 weeks after a nonlethal dose. The changes in breathing frequency were compared with histological changes in the same mice at sacrifice. The increased breathing frequency between 14 and 24 weeks was associated with radiation pneumonitis seen histologically. After 36 weeks, the elevation in breathing frequency above the control value was associated with fibrosis. Comparison of dose-response curves for the pathological changes and for breathing frequency 16, 36, and 52 weeks after irradiation indicated that increases in breathing frequency were associated with increases in the severity of the histological changes scored.

• Research Organization: Gray Lab. of the Cancer Research Campaign, Middlesex, England
• OSTI ID: 6792071
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 84:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BREATH
DATA
DOSE-RESPONSE RELATIONSHIPS
DOSES
DYNAMIC FUNCTION STUDIES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FIBROSIS
HISTOLOGY
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LETHAL DOSES
LUNGS
MAMMALS
MICE
MORTALITY
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
PNEUMONITIS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
SUBLETHAL IRRADIATION
SURVIVAL CURVES
TIME DEPENDENCE
VERTEBRATES
X RADIATION