Replicative activity of lung type 2 cells following lung X irradiation

Journal Article · Wed Jul 01 04:00:00 EDT 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577029· OSTI ID:6272704

Gross, N J; Narine, K R; Colletti-Squinto, L

We investigated the replicative activity of type 2 cells in the lungs of mice at various times from 3 to 22 weeks after 18 Gy of X rays to the thorax. No significant changes were found until 11 weeks after thoracic X irradiation. Thereafter the replicative index of type 2 cells was significantly elevated, rising four to sixfold above that of control, sham-irradiated mice. During the period when the replicative activity of type 2 cells was elevated, the breathing frequency increased and there was histologic evidence of the presence of radiation pneumonitis. The magnitude of each of these indices of pneumonitis correlated significantly with the type 2 cell replicative index, suggesting that type 2 cell replication is related to pneumonitis in extent as well as in chronology. How these changes relate to the pathogenesis of radiation pneumonitis is unclear.

• Research Organization: Hines VA Hospital, IL
• OSTI ID: 6272704
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 111:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CELL DIVISION
CELL PROLIFERATION
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
INJURIES
IONIZING RADIATIONS
LUNGS
MAMMALS
MATHEMATICS
MICE
ORGANS
PATHOGENESIS
PNEUMONITIS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RESPIRATION
RESPIRATORY SYSTEM
RODENTS
STATISTICS
VERTEBRATES
X RADIATION