Quantitative changes in the arterial blood gases of mice following localized irradiation of the lungs

Journal Article · Tue Mar 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576034· OSTI ID:5741527

Siemann, D W ^[1]; Hill, R P

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1. Univ. of Rochester Cancer Center, NY

The arterial pH and partial pressures of oxygen (PaO/sub 2/) and carbon dioxide (PaCO/sub 2/) were evaluated in LAF1 mice 15 and 38 weeks after localized irradiation of the animals' thoraxes. Graded radiation doses of 900 to 1200 rad were administered. These doses resulted in 0 to 100% lethality by 26 weeks (180 days) after irradiation. At 15 weeks after treatment mice receiving radiation doses which would subsequently result in lethality (by 180 days) exhibited significant reductions in their PaO/sub 2/ and elevations in their PaCO/sub 2/ values, respectively. However, there was no clear dose-response relationship between blood gas values and radiation dose, which may reflect the animals' ability to compensate for their poor blood gas exchange by an increased breathing frequency. At 38 weeks after irradiation the blood gas values were abnormal in mice from groups which had normal blood gas values at Week 15 (and no fatalities by Week 26) but in which animal deaths had occurred between Weeks 26 and 38. These data therfore indicated (i) that abnormal blood gas values occurred in the mice prior to fatalities resulting from the acute radiation pneumonitis syndrome and (ii) that mice surviving the initial radiation pneumonitis phase could still succumb to progressive pulmonary toxicity which was reflected by the increasing levels of animal lethality and altered blood gas tensions at the later times.

• OSTI ID: 5741527
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 93:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CHEMISTRY
BODY
BODY AREAS
BODY FLUIDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CHEST
DATA
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
GAS ANALYSIS
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LETHAL DOSES
LUNGS
MAMMALS
MATERIALS
MICE
NONMETALS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PARTIAL BODY IRRADIATION
PH VALUE
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
X RADIATION