Cerebral glucose utilization and blood flow in Huntington's Disease (HD)

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6791601

Phelps, M E; Mazziotta, J C; Wapenski, J; Riege, W; Baxter, L R

Previous studies in the authors' Laboratory have been carried out on 13 patients symptomatic of HD (SHD) and 15 asymptomatic at-risk for HD (ARHD) with a ECAT II and identification of changes in caudate metabolism using an index technique. The authors report now studies of additional 28 subjects (11 SHD, 17 ARHD) studied drug free and compared to age/sex matched controls using the higher resolution NeuroECAT, FDG for glucose utilization (LCMRGlc) and 0-15 water for cerebral blood flow (CBF). Patients had neurological, psychiatric-tests, x-ray CT and were video taped to determine type, timing and amount of choreathetic movements during study. In SHD (disease duration 4.9 +- 2.7 yrs), significant decreases (30%) in LCMRGlc were found in striatum (SHD=19.3 +- 7.7, controls = 29.9 +- 5.8 ..mu.. moles/min/100g) despite no to moderate caudate atrophy on x-ray CT. Hemisphere and cortical CMRGlc were not significantly decreased. There was a significant correlation between disease duration and ratio of caudate to putamen (Cd/Put). Pattern of LCMRGlc and CBF matched in SHD. The caudate to hemisphere LCMRGlc ratio was not different between ARHD and controls except variance was about 4 times greater for ARHD (ARHD=1.21 +- 0.15, controls = 1.28 +- 0.04) indicating presence of subpopulations in ARHD group. Four ARHD subjects had a ratio of 1 Std. Dev. from mean of SHD (no normals had values in this range). The 2 ARHD subjects with lowest caudate LCMRGlc had Cd/Put ratios > 2 Std. Dev. from controls. Results show 1) LCMRGlc abnormalities in all SHD patients and subpopulations in ARHD, 2) metabolic alterations appear to begin in caudate and spread to putamen and that a Cd/Put value of 0.7 should be found at start of symptoms, and 3) cortex and thalamus are relatively spared in ARHD and early SHD.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 6791601
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANTIMETABOLITES
ATROPHY
BIOCHEMICAL REACTION KINETICS
BLOOD FLOW
BODY
BRAIN
CAT SCANNING
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASE INCIDENCE
DISEASES
DRUGS
FLUORODEOXYGLUCOSE
HEREDITARY DISEASES
KINETICS
METABOLISM
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
RADIOISOTOPE SCANNING
REACTION KINETICS
SCINTISCANNING
THALAMUS
TOMOGRAPHY