Local cerebral glucose metabolism (LCMRGlc) in mood disorders

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5872835

Phelps, M E; Baxter, L R; Mazziotta, J C; Schwartz, J M; Gerner, R H

PET studies (LCMRGlc units of ..mu.. moles/min/100g and errors in std. dev.) were performed in patients with unipolar depression (n=11), bipolar depression (n=8), hypomania (n=8) and bipolar mixed states (n=3) in drug free states as well as during spontaneous or drug induced changes in mood, and age/sex matched normals (n=9). The major findings were: bipolar depressed patients had lower (P<0.001) supratentorial CMRGlc (16.7 +- 3.7) than normals (23.6 +- 1.9), hypomanic bipolars (24.7 + 44.6) or unipolars (24.5 +- 3.0). Bipolar mixed (16.4 +- 4.8) were not different from bipolar depressed but were different from all other states (P<0.02). Bipolar depressed and mixed showed increased (30%) supratentorial CMRGlc (P<0.05) with elevated mood (euthymic or hypomanic). Three rapid cycling bipolar patients (2 studies depressed and 1 hypomanic) also showed consistent increases (35%) in supratentorial CMRGlc from depressed to elevated mood state. Unipolar depressed patients had a low LCMRGlc ratio of caudate to hemispheric (c/Hem) (1.18 +- 0.09) compared to bipolar depression (1.30 +- 0.13) or normals (1.32 +- 0.07). Four unipolar patients studied after drug induced recovery showed corresponding return of Cd/Hem ratio to normal. Results of these studies show; delineation of bipolar depressed from unpolar depressed and normals. Separation of mixed biopolar from unipolar and correspondence of the former with bipolar rather than unipolar depression (controversial characterization by other diagnostic criteria), separation of unipolar from normal and bipolar by reduced LCMRGlc of caudate, and direct correspondence of changes in mood state with changes in LCMRGlc independent of whether changes in mood were drug induced or spontaneous.

• Research Organization: UCLA School of Medicine, Los Angeles, CA
• OSTI ID: 5872835
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANTIMETABOLITES
BASAL METABOLISM
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRAL CORTEX
CEREBRUM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MENTAL DISORDERS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
USES