Platelet (/sup 3/H)imipramine binding in affective disorders: trait versus state characteristics

Journal Article · Sun Jun 01 00:00:00 EDT 1986 · Am. J. Psychiatry; (United States)

OSTI ID:5334960

Baron, M; Barkai, A; Gruen, R; Peselow, E; Fieve, R R; Quitkin, F

Platelet (3H)imipramine binding (Bmax) was determined in 67 patients with major affective illness (33 euthymic bipolar, 34 depressed unipolar) and 58 normal control subjects. Bipolar patients had significantly lower Bmax values than did control subjects. The mean Bmax in the unipolar patients was lower than in the control subjects, but the difference was not statistically significant. Dissociation constant (Kd) values did not distinguish patients in either category from control subjects. The significantly lower Bmax in euthymic bipolar patients and the apparent state independence of Bmax in some but not all unipolar patients suggest that platelet imipramine binding may be a trait marker in a subset of affective disorders.

• Research Organization: Columbia Univ. College of Physicians and Surgeons, New York, NY
• OSTI ID: 5334960
• Journal Information: Am. J. Psychiatry; (United States), Journal Name: Am. J. Psychiatry; (United States) Vol. 6; ISSN AJPSA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANTIDEPRESSANTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
CHEMICAL BONDS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
MENTAL DISORDERS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PATIENTS
PSYCHOTROPIC DRUGS
TRACER TECHNIQUES
TRITIUM COMPOUNDS