Effect of desipramine treatment on /sup 3/H-imipramine binding in the blood platelets of depressed patients

Journal Article · Mon Feb 15 04:00:00 EST 1988 · Biol. Psychiatry; (United States)

DOI:https://doi.org/10.1016/0006-3223(88)90290-9· OSTI ID:5175983

Arora, R C; Meltzer, H Y

Platelet imipramine binding (IB) was studied in depressed patients before and after treatment with desipramine for 17-28 days. Administration of desipramine was associated with a significant increase in Bmax. There was a trend for an increase in Kd, but it did not reach statistical significance. The net result of the changes in Bmax and Kd was an increase in IB. There were significant correlations between the change in depression ratings and pretreatment Kd, as well as the change in Kd during treatment. These results suggest that decreased IB is not a trait-dependent marker, but a state-dependent marker for depression. 46 references.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (USA)
• OSTI ID: 5175983
• Journal Information: Biol. Psychiatry; (United States), Journal Name: Biol. Psychiatry; (United States) Vol. 23:4; ISSN BIPCB
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
CHEMOTHERAPY
DISEASES
DRUGS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MATERIALS
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
PATIENTS
PSYCHOTROPIC DRUGS
REACTION KINETICS
THERAPY
TRACER TECHNIQUES
TRITIUM COMPOUNDS