Seasonal variation of imipramine binding in the blood platelets of normal controls and depressed patients

Journal Article · Mon Feb 01 04:00:00 EST 1988 · Biol. Psychiatry; (United States)

DOI:https://doi.org/10.1016/0006-3223(88)90032-7· OSTI ID:5357981

Arora, R C; Meltzer, H Y

Imipramine binding (IB) was studied in the blood platelets from normal controls and depressed patients over a 4-year period (1981-1984) to determine if seasonal variation was present in Bmax or KD. Bimonthly variation in the Bmax of IB was found in normal controls studied longitudinally. No such variation was found when individual values from normal controls were examined on a monthly or seasonal basis. Bmax in depressed patients showed a significant seasonal, but not monthly, variation. KD of IB varied in normal controls using monthly or seasonal data, but not in the probably more reliable bimonthly data. These results suggest that IB studies comparing groups of subjects should match groups for season of the year or, for greater accuracy, month of the year.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (USA)
• OSTI ID: 5357981
• Journal Information: Biol. Psychiatry; (United States), Journal Name: Biol. Psychiatry; (United States) Vol. 23:3; ISSN BIPCB
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
AMINES
ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MATERIALS
MENTAL DISORDERS
MONTHLY VARIATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PATIENTS
PSYCHOTROPIC DRUGS
REACTION KINETICS
SEASONAL VARIATIONS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VARIATIONS