Decreased seasonal mesor of platelet sup 3 H-imipramine binding in depression
- Univ. of California, Irvine (USA)
Seasonal cycles of platelet {sup 3}H-imipramine binding were compared in 49 endogenous unipolar depressed patients and 20 normal volunteers. A significant sinusoidal component was detected in the Bmax of binding in both patients and controls with similar amplitudes and seasonal peaks. However, the yearly average (mesor) of the patient group was significantly lower (20.0%) than that of the normal controls. The results support earlier claims of a diminished platelet binding in endogenous depression and indicate that this decrease was still evident in the presence of a 48.2% (controls) to 65.8% (patients) seasonal variation. Control Bmax values were normally distributed about a best-fit mean (cosinor fit). In contrast, patient values appeared to be bimodally distributed with one mode that was similar to controls and one mode that was substantially lower. In general, psychiatric symptoms failed to distinguish between patients with high and low platelet binding and no correlation was found between Bmax and severity of illness (HAM-D).
- OSTI ID:
- 5735680
- Journal Information:
- Biological Psychiatry; (USA), Journal Name: Biological Psychiatry; (USA) Vol. 29:5; ISSN 0006-3223; ISSN BIPCB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANTIDEPRESSANTS
BIOCHEMICAL REACTION KINETICS
CENTRAL NERVOUS SYSTEM AGENTS
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IMIPRAMINE
ISOTOPE APPLICATIONS
KINETICS
MATHEMATICS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PATIENTS
PROBABILITY
PSYCHOTROPIC DRUGS
REACTION KINETICS
REGRESSION ANALYSIS
SEASONAL VARIATIONS
STATISTICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VARIATIONS