Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Dopamine and serotonin receptors measured in vivo in Huntington's Disease with C-11 n-methylspiperone PET imaging

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6869132
; ; ; ; ; ; ; ; ;

Thirteen patients with the clinical diagnosis of Huntington's Disease (HD) and nine persons at risk to develop the disease were studied by positron emission tomography (PET) after administration of /sup 11/C-n-methylspiperone (NMSP), a tracer with a high affinity for D2 dopamine and, to a lesser degree, for S2 serotonin receptors. All subjects had an X-ray CT scan for positioning and to assess caudate size. Dopamine and serotonin receptor binding (D2 and S2) were estimated by the caudate/cerebellum activity ratio at 43 min. post injection (CA/CB), and frontal cortex/cerebellum (FR/CB), respectively. CA/CB's of HD pts. were lower than age and sex matched controls. However, when corrected by recovery coefficients (RC) for our PET using CT dimensions of the caudate, CA/CB's were higher than normal. The relative total number of D2 receptors (estimated by CA/CB x CT caudate volume) was lower than the controls without or with RC correction.

Research Organization:
The Johns Hopkins Medical Institutions, Baltimore, MD
OSTI ID:
6869132
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

In vivo binding of /sup 3/H-N-methylspiperone to dopamine and serotonin receptors
Journal Article · Sun Mar 08 23:00:00 EST 1987 · Life Sci.; (United States) · OSTI ID:6846946
The effects of age on dopamine receptors measured by positron tomography in the living human brain
Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States) · OSTI ID:6930003
Assessment of dopamine receptor blockade by neuroleptic drugs in the living human brain
Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States) · OSTI ID:6795133

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBELLUM
CEREBRAL CORTEX
CEREBRUM
CHEMICAL BONDS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOPAMINE
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VIVO
INDOLES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MEASURING METHODS
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
PROTEINS
PYRROLES
RADIOISOTOPES
RADIONUCLIDE ADMINISTRATION
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
RADIORECEPTOR ASSAY
RECEPTORS
SEROTONIN
SPIPERONE
SYMPATHOMIMETICS
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
TRYPTAMINES
USES