Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 navy fuel (Case No. 8008-20-6) in B6C3F1 mice (dermal studies). Technical report series

Technical Report · Mon Sep 01 04:00:00 EDT 1986

OSTI ID:6788229

Toxicology and carcinogenesis studies were conducted by applying marine diesel fuel or JP-5 navy fuel to clipped dorsal interscapular skin of male and female B6C3F1 mice to determine both systemic and dermal effects. Doses for the 2-year studies were set by conducting 14-day and 13-week studies. Doses of 2000-40,000 mg/kg marine diesel fuel were applied neat in the 14-day studies; in the 13-week studies, doses of 250-4000 mg/kg marine diesel fuel in acetone were applied with a dose volume of 0.1 ml. Doses of 5000-40,000 mg/kg JP-5 navy fuel in ethanol were applied in the 14-day studies with a dose volume of 0.5 ml; in the 13-week studies, doses of 500-8000 mg/kg JP-5 navy fuel in acetone were applied with a dose volume of 0.2 ml. For the 2-year studies, doses were selected which did not cause deaths, decrease body weight gain, or produce excessive dermatitis in the 14-day or 13-week studies. Under the conditions of these 2-year dermal studies, marine diesel fuel at doses of 250 and 500 mg/kg resulted in dose-related increased incidences of squamous-cell neoplasms of the skin (primarily carcinomas), providing equivocal evidence of carcinogenicity for male and female B6C3F1 mice. The sensitivity for detecting systemic carcinogenicity in female mice dosed with marine diesel fuel was reduced by poor survival. Under the conditions of these 2-year dermal studies, JP-5 navy fuel at doses of 250 and 500 mg/kg provided no evidence of carcinogenicity for male and female B6C3F1 mice.

• Research Organization: National Toxicology Program, Research Triangle Park, NC (USA)
• OSTI ID: 6788229
• Report Number(s): PB-87-131678/XAB; NTP-TR-310
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020900 -- Petroleum-- Environmental Aspects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
CARCINOGENESIS
DIESEL FUELS
FUELS
JET ENGINE FUELS
LABORATORY ANIMALS
MAMMALS
MICE
PATHOGENESIS
PETROLEUM PRODUCTS
RATS
RODENTS
TOXICITY
VERTEBRATES