Urinary formic acid as an indicator of occupational exposure to formic acid and methanol
Journal Article
·
· Am. Ind. Hyg. Assoc. J.; (United States)
A sampling strategy was developed to detect personal exposure to methanol and formic acid vapors. Formic acid is the metabolic end product of methanol, and part of inhaled formic acid is excreted directly in urine, so that urinary formic acid would reveal exposure to both agents. A linear relationship to inhaled vapors, however, could be shown only if urinary sampling were delayed until 16 hr (next morning) after exposure. Exposure to methanol vapor at the current Finnish hygienic limit level (200 ppm) produced 80 mg formic acid/g creatinine; exposure to formic acid at the hygienic limit (5 ppm) caused 90 mg/g creatinine. The similarity of these figures may indicate a common toxicological foundation of these empirically set values.
- Research Organization:
- Kuopio Regional Institute of Occupational Health, Finland
- OSTI ID:
- 6785650
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 1; ISSN AIHAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
FLUIDS
FORMIC ACID
GASES
HYDROXY COMPOUNDS
INHALATION
INTAKE
MATERIALS
MAXIMUM PERMISSIBLE EXPOSURE
METABOLISM
METABOLITES
METHANOL
MONOCARBOXYLIC ACIDS
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
SAFETY STANDARDS
STANDARDS
URINE
VAPORS
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBOXYLIC ACIDS
FLUIDS
FORMIC ACID
GASES
HYDROXY COMPOUNDS
INHALATION
INTAKE
MATERIALS
MAXIMUM PERMISSIBLE EXPOSURE
METABOLISM
METABOLITES
METHANOL
MONOCARBOXYLIC ACIDS
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
SAFETY STANDARDS
STANDARDS
URINE
VAPORS
WASTES