Biological monitoring of dichloropropene: Air concentrations, urinary metabolite, and renal enzyme excretion

Journal Article · Sat Jul 01 04:00:00 EDT 1989 · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1989.9935885· OSTI ID:5414989

Osterloh, J D; Wang, R; Schneider, F; Maddy, K ^[1]

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1. Univ. of California, San Francisco (USA)

Fifteen applicators of dichloropropene (DCP) were studied for personal air exposure to DCP, excretion of the metabolite of DCP (3CNAC), and excretion of the renal tubular enzyme, N-acetyl glucosaminidase (NAG). Each was studied for four 6-8 h consecutive intervals following baseline determinations of 3CNAC and NAG excretion. In accord with pilot data, 24-h urinary excretion of 3CNAC (mg) correlated well with exposure product for DCP (min exposed.mg/m{sup 3}), r = 0.854, p less than .001. A more precise correlation of the air exposure product with urinary excretion of 3CNAC was discerned by using the morning urine after the previous day of exposure (micrograms/mg of creatinine), r = 0.914, p less than .001. Four workers had clinically elevated activity of NAG (greater than 4 mU/mg creatinine) in any of their urine collections after baseline. Nine workers showed greater than 25% increases in NAG excretion when compared to baseline. Dichloropropene air exposure products of greater than 700 mg.min/m{sup 3} or excretion of greater than 1.5 mg 3CNAC/d distinguished abnormally high daily excretion of NAG. These data demonstrate a firm positive relationship between air exposure and internal exposure, and a possible subclinical nephrotoxic effect in DCP workers.

• OSTI ID: 5414989
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 44:4; ISSN AEHLA; ISSN 0003-9896
• Country of Publication: United States
• Language: English

Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
AIR POLLUTION MONITORING
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
ECOLOGICAL CONCENTRATION
ENZYMES
EXCRETION
GLYCOSYL HYDROLASES
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROLASES
KIDNEYS
MASS SPECTROSCOPY
METABOLISM
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PERSONNEL
POLLUTION
SPECTROSCOPY
TOXICITY
TUBULES