pi-meson at TRIUMF using mouse L5178Y cells. [Pions, /sup 137/Cs, x-rays]

Conference · Mon Sep 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6784757

Nakamura, N ^[1]; Lam, G K.Y.; Sakamoto, K; Okada, S

---

1. Univ. of Tokyo, Japan

Radiobiological parameters, cell killing, induction of mutations resistant to 6-thioguanine and to methotrexate, and DNA scissions were investigated at the plateau region and peak region of the pion beams of TRIUMF under a preclinical beam condition. The relative biological effectiveness (RBE) of four parameters at the plateau region were nearly 1 using gamma-rays or X rays as the standard radiations. RBE values at the peak regions were varied from one biological parameter to the other. The RBE of cell killing was dependent upon radiation dose; an RBE of 1.9 decreased gradually to 1.2 with an increased radiation dose. The RBE of mutations resistant to 6-thioguanine was dose-dependent and decreased from 1.7 to 1.3 when the dose was increased, while the RBE of mutations resistant to methotrexate was a constant, 1.0. The RBE of DNA scission was a constant 0.7. The radiobiological significance of cell killing and of mutagenesis in pion radiotherapy will be discussed.

• OSTI ID: 6784757
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 6:9
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ALKALI METAL ISOTOPES
AMINES
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BOSONS
CELL CULTURES
CELL KILLING
CESIUM 137
CESIUM ISOTOPES
COMPARATIVE EVALUATIONS
CYCLIC ACCELERATORS
CYCLOTRONS
DNA
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY TRANSFER
GUANINE
HADRONS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
ISOCHRONOUS CYCLOTRONS
ISOTOPES
LET
MAMMALS
MESONS
METHOTREXATE
MICE
MUTAGENESIS
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIONS
PIONS MINUS
PSEUDOSCALAR MESONS
PURINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RBE
RODENTS
STRAND BREAKS
TRIUMF CYCLOTRON
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES