Radiobiology of pions at TRIUMF

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90556-9· OSTI ID:5477121

Skarsgard, L D; Palcic, B; Douglas, B G; Lam, G K.Y.

Radiobiological studies at TRIUMF of the effects of pion beams have been carried out using cultured cells, mice and pigs. CHO cells in gel/medium were used for RBE determinations throughout the dose distributions. The RBE was shown to increase with depth in the stopping region, while the average RBE value decreased with increasing width of the stopping peak and also increased with increasing field size. The results suggest that the effects of peak width and field size will aproximately cancel out when treatment volumes are changed, provided that all three dimensions are changed more or less proportionally. The peak center RBE values ranged from 1.2-1.3 for single doses. The oxygen enhancement ratio (OER) for pions was 2.2 compared to 2.8 for X rays. Split dose recovery was found to be somewhat reduced in the peak region. In vivo studies with mouse and pig skin have been done for 1 to 20 fractions. For mouse skin, pions showed an RBE of 1.5-1.6 for fraction numbers greater than 10. The RBE for pig skin was 1.4 for early reactions, but it may be higher for medium term reactions.

• Research Organization: Univ. of British Columbia, Vancouver, Canada
• OSTI ID: 5477121
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:12; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BOSONS
CYCLIC ACCELERATORS
CYCLOTRONS
DOMESTIC ANIMALS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
HADRONS
IONIZING RADIATIONS
ISOCHRONOUS CYCLOTRONS
MAMMALS
MESONS
MICE
ORGANS
OXYGEN ENHANCEMENT RATIO
PIONS
PIONS MINUS
PSEUDOSCALAR MESONS
RADIATION EFFECTS
RADIATIONS
RADIOBIOLOGY
RBE
RODENTS
SKIN
SWINE
TRIUMF CYCLOTRON
VERTEBRATES
X RADIATION