Radiosensitizing effect of misonidazole in acute and fractionated irradiation of a human osteosarcoma xenograft. [/sup 60/Co]

Conference · Mon Sep 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6784041

Rofstad, E K; Brustad, T

The radiosensitizing effect of misonidazole (Ro-07-0582) in acute and fractionated irradiation of a human osteosarcoma grown in the athymic mutant nude mouse was studied. Tumor regrowth delay was used as a measure of response. The enhancement ratio of misonidazole was found to be 1.45 for an actue dose of 12.50 Gy and 1.25 for four fractions of 3.75 Gy, delivered over four consecutive days. It is concluded that the present osteosarcoma xenograft reoxygenated inadequately during the three day period which elapsed from the first to the fourth fraction of 3.75 Gy.

• Research Organization: Norwegian Radium Hospital, Montebello
• OSTI ID: 6784041
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:9; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DISEASES
DRUGS
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
GRAFTS
GROWTH
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
INHIBITION
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTRAPERITONEAL INJECTION
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MICE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITRO COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OSTEOSARCOMAS
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SARCOMAS
SIDE EFFECTS
SKELETAL DISEASES
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES