Influence of misonidazole on the radiosensitivity of transplantable transitional cell bladder carcinoma in mice
Journal Article
·
· Invest. Urol.; (United States)
OSTI ID:5576365
The radiosensitizing properties of misonidazole (Ro-07-0582; NSC-26137) were evaluated in a leg transplanted model of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide (FANFT) induced transitional cell bladder carcinoma in C3H/He mice. Animals bearing tumor received fractionated radiation of 400 rads X 5 or 600 rads X 5. Other groups with the same radiation doses were treated with misonidazole (0.75 mg per g) before each radiation fraction. Radiation alone was effective in prolonging Mean Survival Time, 17 per cent for 400 rads X 5 and 45 per cent for 600 X 5, with an associated delay in tumor growth. Misonidazole in the 600 rads X 5 group showed a radiosensitizing effect by further slowing tumor growth and prolonging Mean Survival Time by 80 per cent over the control and 24 per cent over radiation alone. Misonidazole alone did not show notable cytotoxic effects.
- OSTI ID:
- 5576365
- Journal Information:
- Invest. Urol.; (United States), Journal Name: Invest. Urol.; (United States) Vol. 19:1; ISSN INURA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BLADDER
BODY
CARCINOMAS
DISEASES
DRUGS
FRACTIONATED IRRADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MAMMALS
MEDICINE
MICE
MISONIDAZOLE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
URINARY TRACT
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BLADDER
BODY
CARCINOMAS
DISEASES
DRUGS
FRACTIONATED IRRADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MAMMALS
MEDICINE
MICE
MISONIDAZOLE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
URINARY TRACT
VERTEBRATES