Inhalation of baby talc powder by hamsters
Groups of 50 male and 50 female Syrian golden hamsters are being exposed to baby talc powder aerosol 3 min/day, 30 min/day, and 150 min/day, respectively, for 30 exposure days, and for 30 min/day and 150 min/day, respectively, for 300 exposure days. Mean total aerosol concentration is approximately 28 ..mu..g/l, mean respirable fraction of the aerosol is approximately 8 ..mu..g/l. Two groups of 25 male and 25 female control hamsters are receiving sham exposures 150 min/day for 30 and 300 exposure days, respectively. After the 30- and 300-day exposures the hamsters are being maintained for life span observations. At death, lung, trachea, larynx, liver, kidneys, adrenals, heart, stomach, ovaries and uterus, or testicles, and tissues showing gross lesions, are collected for histopathologic examination. Evaluative criteria are histopathologic findings, life span and body weights. Experimental data and results are incomplete at this time. Final results will be available by spring 1975. Preliminary pathologic evaluation indicates that systemic amyloidosis is the major cause of death in the exposed as well as in the control animals. Kidneys, adrenal glands, and liver are most frequently involved. Inhalation of baby talc powder has caused no obvious pulmonary lesions and no decreased life span in the exposed hamsters evaluated to date as compared with their controls.
- OSTI ID:
- 6783174
- Resource Relation:
- Conference: 18. international congress on occupational health, Brighton, England, 14 Sep 1975
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AEROSOLS
INHALATION
TALC
BIOLOGICAL EFFECTS
ADRENAL GLANDS
HAMSTERS
HISTOLOGY
KIDNEYS
LIFE SPAN
LIVER
LUNGS
QUANTITY RATIO
TRACHEA
WEIGHT
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BODY
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
ENDOCRINE GLANDS
GLANDS
INTAKE
MAGNESIUM COMPOUNDS
MAGNESIUM SILICATES
MAMMALS
MINERALS
ORGANS
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
SILICATES
SILICON COMPOUNDS
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)