Chronic inhalation of cobalt oxide and cigarette smoke by hamsters

Journal Article · Fri Jul 01 04:00:00 EDT 1977 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/0002889778507627· OSTI ID:5422502

Wehner, A P; Busch, R H; Olson, R J; Craig, D K

Exposure of hamsters to CoO aerosol (10 g/L, 7 hrs./day, 5 days/week) caused pneumoconiosis but affected neither the life span nor the incidence of other than pneumoconiotic lesions. No carcinogenic effects of CoO were observed. While cigarette smoke exposures significantly increased the incidence of certain types of other than pneumoconiotic lesions including tumors, they also increased the life span of the smoke-exposed animals significantly. The latter phenomenon may account for the higher tumor incidence in the smoke-exposed animals. No effect of the smoke exposures on incidence and degree of pneumoconiosis was observed. The mean body weights of the smoke-exposed groups were significantly reduced.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA
• OSTI ID: 5422502
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 38:7; ISSN AIHAA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
CHRONIC INTAKE
COBALT COMPOUNDS
COBALT OXIDES
COLLOIDS
DISEASES
DISPERSIONS
DUSTS
HAMSTERS
INHALATION
INTAKE
LIFE SPAN
LUNGS
MAMMALS
NEOPLASMS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PNEUMOCONIOSES
POLLUTION
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SMOKES
SOLS
TOBACCO SMOKES
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES