Chronic inhalation of cigarette tobacco smoke by rats
Specific-pathogen-free rats were exposed by inhalation to cigarette tobacco smoke in a regimen considered to result in a maximal tolerated dose. Total pulmonary deposition of smoke particulates from a single cigarette was 0.25 mg in young rats. Rats were exposed to smoke from 7 cigarettes per day for up to 2.5 years, at which time 30% of the exposed rats remained alive. Mortality of smoke-exposed animals was not different from that of untreated and sham-exposed controls. Nine percent of the exposed animals had tumors in the respiratory tract as opposed to only 1% tumor incidence among the control animals. Smoke exposure did not change the total percent of animals with at least one tumor at some site in the body. However, relative to controls, exposed rats had significantly fewer tumors in the hypophysis, hematopoietic-lymphoid system, uterus, and ovary and an increased number of tumors in the dermis in addition to the respiratory tract. Several non-neoplastic changes were observed throughout the respiratory tract. Hyperplastic and metaplastic areas were seen in the epithelium of the nasal turbinates, larynx, and trachea of exposed animals at death. Lungs of exposed rats contained areas of focal alveolitis.
- Research Organization:
- Oak Ridge National Lab., TN (USA); National Inst. of Environmental Health Sciences, Research Triangle Park, NC (USA); National Cancer Inst., Bethesda, MD (USA). Div. of Cancer Cause and Prevention
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5260762
- Report Number(s):
- CONF-791002-7
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
COLLOIDS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DISEASES
DISPERSIONS
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
GRAPHS
INFORMATION
INHALATION
INTAKE
JUVENILES
MAMMALS
NEOPLASMS
NUMERICAL DATA
PATHOLOGICAL CHANGES
RATS
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SMOKES
SOLS
TABLES
TOBACCO SMOKES
VERTEBRATES