Increased life span and decreased weight in hamsters exposed to cigarette smoke
Five groups of fifty-one 2-month-old male Syrian golden hamsters received three 10-minute exposures to cigarette smoke per day, 5 days per week, for the duration of their lives. Three of the groups were also chronically exposed to aerosols of chrysotile asbestos, cobalt oxide, and nickel oxides, respectively. The fourth group received twelve weekly injections of 0.25 mg of diethylnitrosamine. The smoke-exposed groups lived significantly (P is less than .01) longer than their sham-exposed cohorts and untreated controls. Their mean body weights were significantly (P is less than .01) lower than in the sham-exposed groups. The hypothesis is proposed that delayed onset of amyloidosis and lower body weight in the smoke-exposed hamsters may have been responsible for their increased life spans. It is hypothesized that cigarette smoke affected the immune system of the animals, resulting in retardation of amyloidosis, a frequent cause of death in hamsters.
- Research Organization:
- Battelle Pacific Northwest Labs., Richland, WA
- OSTI ID:
- 7317330
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 31:3; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINES
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
CARCINOGENS
CHALCOGENIDES
COBALT COMPOUNDS
COBALT OXIDES
COLLOIDS
DISEASES
DISPERSIONS
HAMSTERS
IMMUNITY
LIFE SPAN
MAMMALS
NICKEL COMPOUNDS
NICKEL OXIDES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
RESIDUES
RODENTS
SMOKES
SOLS
SYNERGISM
TOBACCO SMOKES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WEIGHT