Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1981-September 30, 1982

Technical Report · Wed Sep 01 04:00:00 EDT 1982

OSTI ID:6782743

Evans, H H

Of six BHK strains surviving infection with irradiated herpes virus (HSV), three were found to be significantly more sensitive to ionizing radiation than the parental BHK cells. Two of these (strains V1 and V2) were studied in more detail and found to exhibit hypersensitivity to the cytotoxic effects of ethylmethane sulfonate (EMS), methylmethane sulfonate (MMS), and N-methyl-N'-nitro-nitrosoguanidine (MNNG), but not to radiation with uv light. The induction of mutations by EMS was higher for strain V1 and lower for strain V2 than in the case of the parental BHK cells. Possibly strain V1 is deficient in the repair of a mutagenic lesion induced by EMS while strain V2 may be more efficient in this repair as compared to the wild-type strain.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (USA)
• DOE Contract Number: AC02-77EV04472
• OSTI ID: 6782743
• Report Number(s): DOE/EV/04472-5; ON: DE83000292
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
DNA
EMS
ESTERS
MAMMALS
METHYL METHANESULFONATE
MUTAGENESIS
MUTAGENS
MUTATION FREQUENCY
NITROSO COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOSENSITIVITY
RECOVERY
REPAIR
SULFONIC ACID ESTERS
VERTEBRATES