Isolation and characterization of BHK cells sensitive to ionizing radiation and alkylating agents
Journal Article
·
· Radiat. Res.; (United States)
A host-cell viral suicide enrichment procedure was used to isolate BHK strains sensitive to ionizing radiation. Of six strains surviving infection with irradiated herpes simplex virus (HSV), three were found to be more sensitive to ionizing radiation than the parental BHK cells. Strains V1 and V2 were studied in more detail and found to exhibit hypersensitivity to ethyl methanesulfonate (EMS), methyl methanesulfonate, and N-methyl-N'-nitro-N-nitrosoguanidine, but not to uv radiation. Susceptibility to mutation in response to EMS was also compared in BHK and strains V1 and V2. The frequency of induction of ouabain-resistant cells was 140% of the parental strain in the case of strain V1 and 58% of the parental strain in the case of strain V2.
- Research Organization:
- Case Western Reserve Univ., Cleveland, OH
- DOE Contract Number:
- AC02-77EV04472
- OSTI ID:
- 6600787
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1981-September 30, 1982
Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1980-October 31, 1981
Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Final report, August 1, 1977-January 31, 1985
Technical Report
·
Wed Sep 01 00:00:00 EDT 1982
·
OSTI ID:6782743
Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Progress report, November 1, 1980-October 31, 1981
Technical Report
·
Thu Oct 01 00:00:00 EDT 1981
·
OSTI ID:5296815
Relationship of DNA repair processes to mutagenesis and carcinogenesis in mammalian cells. Final report, August 1, 1977-January 31, 1985
Technical Report
·
Thu Jan 31 23:00:00 EST 1985
·
OSTI ID:5909823
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBONIC ACID DERIVATIVES
DISEASES
ELECTROMAGNETIC RADIATION
EMS
ESTERS
GUANIDINES
HERPES SIMPLEX
HOST-CELL REACTIVATION
IN VITRO
INFECTIOUS DISEASES
IONIZING RADIATIONS
METHYL METHANESULFONATE
MICROORGANISMS
MUTAGENS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARASITES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
VIRAL DISEASES
VIRUSES
X RADIATION
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBONIC ACID DERIVATIVES
DISEASES
ELECTROMAGNETIC RADIATION
EMS
ESTERS
GUANIDINES
HERPES SIMPLEX
HOST-CELL REACTIVATION
IN VITRO
INFECTIOUS DISEASES
IONIZING RADIATIONS
METHYL METHANESULFONATE
MICROORGANISMS
MUTAGENS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PARASITES
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SULFONIC ACID ESTERS
ULTRAVIOLET RADIATION
VIRAL DISEASES
VIRUSES
X RADIATION