Regulation of IgE antibody production by serum molecules. II. Strain-specificity of the suppressive activity of serum from complete Freund's adjuvant-immune low responder mouse donors

Journal Article · Thu Jun 01 04:00:00 EDT 1978 · J. Immunol.; (United States)

OSTI ID:6781682

Katz, D H; Tung, A S

IgE antibody production in mice of high and low IgE responder phenotypes, respectively, can be appreciably enhanced in magnitude after low-dose whole-body x irradiation. Such enhanced responses, as well as adoptive secondary IgE responses, can be markedly suppressed by passive transfer of CFA-immune serum in low responder strains, but not in high responder strains. The studies presented here demonstrate that the suppressive activity of CFA-immune serum on IgE antibody production is strain specific. This is true even in reciprocal combinations of low IgE responder SJL and C57BL/6 mice, in which it was shown that serum capable of suppressing mice of the isologous strain was ineffective in diminishing IgE antibody production in the other low responder strain. Absence of suppressive activity in CFA-immune sera obtained from H-2 haplotypes while sharing many similarities in the background genome and, conversely, effective suppressive activity of H-2 congenic donor sera when H-2-identities between donor and recipient mice existed, strongly suggested a role, at least in part, of H-2 genes in dictating the strain specificity of such suppressive activity. Additional experiments provided evidence for a possible role of macrophages in catabolism of the active molecules in CFA-immune sera. These observations, together with those presented in the preceding paper, may provide valuable insight toward successful development of appropriate manipulations that could ultimately convert high IgE responder individuals into low responders.

• Research Organization: Scripps Clinic and Research Foundation, La Jolla, CA
• OSTI ID: 6781682
• Journal Information: J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 120:6; ISSN JOIMA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GENETIC VARIABILITY
GLOBULINS
IMMUNE REACTIONS
IMMUNE SERUMS
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION