Quantitative analysis by digital computer of Tc-99m N-pyridoxyl-5-methyltryptophan (Tc-99m PMT) hepatogram in diffuse parenchymal liver diseases

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6781355

Narabayashi, I; Ishido, N; Sugimura, K; Nabeshima, K; Sugimura, C; Matsuo, M; Kimura, S; Kajita, A

Tc-99m N-pyridoxyl-5 methyltryptophan (Tc-99m PMT) hepatograms were analyzed to provide information about the liver and bile duct. Calculations were based on a 4 compartmental model and included corrections for blood, tissue, liver and bile backgrounds. The time-activity curves for Tc-99m PMT in the cardiac region were described as the sum of 2 exponential functions, while curves for the hepatic region were described as the sum of 3 exponential components. The measured hepatograms were compared with simulated hepatograms and good agreement between the two curves showed that the compartmental model adequately described the blood and bile activities in vivo. Hepatic excretion rates were 0.179 +- 0.028 in 3 normal subjects. 0.102 +- 0.012 in 4 patients of chronic hepatitis and 0.116 +- 0.061 in 6 patients of liver cirrhosis. In the cases of diffuse parenchyal liver diseases, there were lower rate constants for the excretion from the liver to the bile ducts than in normals and the relative distribution values also larger than normal. Prior to the development of this compartmental model, no useful kinetic model had been found which could satisfactorily explain the time-activity curves. Experience in human studies proves this method to be accurate in determining the rate constants for hepatobiliary transport of Tc-99m PMT.

• Research Organization: Kobe Univ. School of Medicine, Kobe
• OSTI ID: 6781355
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
AROMATICS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BIOLOGICAL MATERIALS
BLOOD
BLOOD CIRCULATION
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
COMPUTERS
CORRECTIONS
COUNTING TECHNIQUES
DATA ANALYSIS
DIAGNOSIS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DIGITAL COMPUTERS
DISEASES
DRUGS
GLANDS
HEPATITIS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INDOLES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIVER
LIVER CIRRHOSIS
MATERIALS
MATHEMATICAL MODELS
METABOLISM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PYRROLES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
TISSUES
TRACER TECHNIQUES
TRYPTOPHAN
USES
YEARS LIVING RADIOISOTOPES