Comparison of biokinetics and biliary imaging parameters of four /sup 99m/Tc iminodiacetic acid derivatives in normal subjects

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198302000-00008· OSTI ID:6257229

Bobba, V V; Krishnamurthy, G T; Kingston, E; Brown, P H; Eklem, M; Turner, F E

The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake, and excretion t-1/2) and the imaging parameters (the time of appearance of the common bile duct, gallbladder, and duodenum) were determined in 34 normal subjects using /sup 99m/Tc diethyl (EIDA), /sup 99m/Tc dimethyl (HIDA), /sup 99m/Tc paraisopropyl (PIPIDA), and /sup 99m/Tc parabutyl (PBIDA) iminodiacetic acid derivatives. The blood and hepatic clearance of the four agents were significantly different (P less than 0.05) from each other. The 24-hour urinary excretion of PBIDA was significantly lower (P less than 0.05) than the urinary excretion of the other three agents. There was no difference among the four agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20 to 40 minutes with all four agents. However, gallbladder intensity continued to increase up to 3 hours. It is concluded that in the presence of normal liver function, all four /sup 99m/Tc IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any one of the four agents will meet the clinican's need satisfactorily.

• Research Organization: Nuclear Medicine Service, Veterans Administration Medical Center, Portland, Oregon
• OSTI ID: 6257229
• Journal Information: Clin. Nucl. Med.; (United States), Journal Name: Clin. Nucl. Med.; (United States) Vol. 8:2; ISSN CNMED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETIC ACID ESTERS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
BLOOD-PLASMA CLEARANCE
BODY
CARBOXYLIC ACID ESTERS
CLEARANCE
COMPARATIVE EVALUATIONS
DIAGNOSTIC USES
DIGESTIVE SYSTEM
ESTERS
EXCRETION
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PHARMACOLOGY
RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
UPTAKE
USES
YEARS LIVING RADIOISOTOPES