Comparison of biokinetics and biliary imaging parameters of four /sup 99m/Tc iminodiacetic acid derivatives in normal subjects
The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake, and excretion t-1/2) and the imaging parameters (the time of appearance of the common bile duct, gallbladder, and duodenum) were determined in 34 normal subjects using /sup 99m/Tc diethyl (EIDA), /sup 99m/Tc dimethyl (HIDA), /sup 99m/Tc paraisopropyl (PIPIDA), and /sup 99m/Tc parabutyl (PBIDA) iminodiacetic acid derivatives. The blood and hepatic clearance of the four agents were significantly different (P less than 0.05) from each other. The 24-hour urinary excretion of PBIDA was significantly lower (P less than 0.05) than the urinary excretion of the other three agents. There was no difference among the four agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20 to 40 minutes with all four agents. However, gallbladder intensity continued to increase up to 3 hours. It is concluded that in the presence of normal liver function, all four /sup 99m/Tc IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any one of the four agents will meet the clinican's need satisfactorily.
- Research Organization:
- Nuclear Medicine Service, Veterans Administration Medical Center, Portland, Oregon
- OSTI ID:
- 6257229
- Journal Information:
- Clin. Nucl. Med.; (United States), Vol. 8:2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ACETIC ACID ESTERS
BLOOD-PLASMA CLEARANCE
DIAGNOSTIC USES
EXCRETION
UPTAKE
TECHNETIUM 99
BILIARY TRACT
COMPARATIVE EVALUATIONS
ISOMERIC NUCLEI
LIVER
PATIENTS
PHARMACOLOGY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
CLEARANCE
DIGESTIVE SYSTEM
ESTERS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques