Pharmacokinetics of hepatobiliary imaging agents in rats: concise communication. [/sup 99m/Tc-pyridoxylidene glutamate; /sup 99m/Tc-N-(2,6-dimethyl-phenylcarbamoylmethyl) iminodiacetic acid; /sup 131/I-rose bengal]
The distribution and elimination kinetics of Tc-99m pyridoxylidene glutamate (Tc-99m PG), of Tc-99m N-(2,6-dimethyl-phenylcarbamoylmethyl)iminodiacetic acid (Tc-99m HIDA), and of I-131 rose bengal in blood were quantitated after i.v. injection in rats. This was performed by use of a unique indwelling catheter that externalizes the systemic circulation, permitting continuous monitoring of blood radioactivity. The blood activity-time curves of Tc-99m PG and Tc-99m HIDA are described by the sum of three exponential functions. Only two exponentials are required in the case of I-131 rose bengal. The rank order for the rates of loss from blood was Tc-99m HIDA > Tc-99m PG > I-131 rose bengal. Bile was collected after administration of Tc-99m HIDA and Tc-99m PG. The total excretion of radioactivity over a 70-min period amounted to 65.7% and 42.8% of the dose of Tc-99m HIDA and Tc-99m PG, respectively. A linear compartmental kinetic model was developed to account for the disappearance from blood and the biliary excretion of these radiopharmaceuticals in rats.
- Research Organization:
- Veterans Administration Hospital Nuclear Medicine Service, Lexington, KY
- OSTI ID:
- 6548154
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 20:1
- Country of Publication:
- United States
- Language:
- English
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Hepatic clearance mechanism of /sup 99m/Tc-HIDA and its effect on quantitation of hepatobiliary function concise communication. [HIDA = N(2,6-dimethylphenylcarbamoylmethyl) iminodiacetic acid; dogs]
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETIC ACID ESTERS
RADIOPHARMACEUTICALS
BILIARY TRACT
SCINTISCANNING
CARBAMIC ACID ESTERS
IMINES
IODINE 131
LIVER
PYRIDOXYLIDENEGLUTAMATE
BLOOD-PLASMA CLEARANCE
EXCRETION
TISSUE DISTRIBUTION
ROSE BENGAL
TECHNETIUM 99
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
ISOMERIC NUCLEI
LABELLED COMPOUNDS
RATS
AMINO ACIDS
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
DYES
ESTERS
GLANDS
GLUTAMIC ACID
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INDICATORS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
REAGENTS
RODENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics