Defective natural killer (NK) cell activity in a rat burn model
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:6778157
In this report they present data on the spontaneous cytotoxic (NK) activity of scalded rat splenic lymphocytes. Sprague-Dawley rats (220-250 grams) were given 40% total body surface area full thickness burn injury by immersing the anesthetized rats in 90/sup 0/C water. Groups of rats were sacrificed at 1,2,4 and 7 day post burn (DPB). Splenic lymphocytes were tested for their ability to lyse YAC-1 target cells in a /sup 51/Cr release assay by incubating /sup 51/Cr-labelled YAC cells with lymphocytes at effector to target (E:T) ratios of 200:1 to 12:1. NK activity of the splenic lymphocytes from scalded rats was observed to be suppressed at all E:T ratios as early as 1 DPB. This decrease was observed at all time periods of study. Their present observations and previous findings of suppressed lymphoproliferative responses in scalded rats support similar findings in human studies, thereby making the rat a good model of immune function studies following thermal injury.
- Research Organization:
- Shriners Burns Institute, Galveston, TX
- OSTI ID:
- 6778157
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
BURNS
CELL PROLIFERATION
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
IMMUNE REACTIONS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
NUCLEI
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
BURNS
CELL PROLIFERATION
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
IMMUNE REACTIONS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
NUCLEI
RADIOISOTOPES
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TRACER TECHNIQUES
VERTEBRATES