The antiviral effectiveness of butylated hydroxytoluene on herpes cutaneous infections in hairless mice

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-170-41425· OSTI ID:6777851

Keith, A D ^[1]; Arruda, D; Snipes, W; Frost, P

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1. Pennsylvania State Univ., University Park

Hairless mice, cutaneously infected with herpes simplex virus type 1 (HSV-1), were treated topically with butylated hydroxytoluene (BHT). The effectiveness of BHT in shortening the duration of infections was assayed under three conditions. In the first experiments, mice undergoing primary infections with no prior immunity to HSV-1 were utilized. These animals tended to develop deep lesions that were not typical of recurrent HSV-1 infections in humans. A second set of experiments utilized mice that had recovered from a primary infection and that were immunosuppressed by ..gamma.. irradiation. Immunosuppression was essential for the full development of lesions upon reinfection. The lesions in these animals remained more localized with less tendency to spread into deep tissues. A third set of experiments utilized animals that were subcutaneously inoculated with human serum ..gamma..-globulin 24 hr prior to infection. Lesions on these animals also remained localized and did not penetrate into deep tissues. Under all three conditions, BHT was found to be effective in reducing the clearance time of HSV-1 cutaneous lesions when applied topically to the infected area.

• OSTI ID: 6777851
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 170:2; ISSN PSEBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BUTYL RADICALS
CRESOLS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLOBULINS
GLOBULINS-GAMMA
HERPES SIMPLEX
HYDROXY COMPOUNDS
IMMUNOSUPPRESSION
INACTIVATION
INFECTIOUS DISEASES
IONIZING RADIATIONS
MAMMALS
MICE
ORGANIC COMPOUNDS
PHENOLS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADICALS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN DISEASES
VERTEBRATES
VIRAL DISEASES