Neptunium-237 inhalation in rats

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198612000-00005· OSTI ID:6775632

Sullivan, M F; Ruemmler, P S; Buschbom, R L

Groups of rats were exposed to aerosols of /sup 237/Np nitrate to determine clearance rates, retention and distribution at various intervals after inhalation. Initial lung burdens (ILB) after /sup 237/Np inhalation by three treatment groups were 0.12, 0.19 and 0.37 mu Ci/kg, respectively. Radiochemical analyses of animals killed at 4, 8, 14, 28 and 90 d, as well as data for others maintained until they became moribund, showed that their lung clearance followed a three-compartment model, clearance half-times for which were 1, 35, and 10,000 d, respectively. Only 3% of the ILB was retained after 90 d; 12% of that burden had translocated to the skeleton at 750 d; the half-time for skeletal retention was 2500 d. A single tumor was the only malignancy detected in the lungs of the 35 animals allowed to survive the early phase of the study.

• Research Organization: Pacific Northwest Lab., Richland, WA
• OSTI ID: 6775632
• Journal Information: Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 6; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CLEARANCE
COLLOIDS
DISPERSIONS
DISTRIBUTION
EXCRETION
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
NEPTUNIUM 237
NEPTUNIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RETENTION
RODENTS
SOLS
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES