Deposition and early disposition of inhaled /sup 233/UO/sub 2/(NO/sub 3/)/sub 2/ and /sup 232/UO/sub 2/(NO/sub 3/)/sub 2/ in the rat

Journal Article · Mon Dec 01 04:00:00 EST 1986 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198612000-00006· OSTI ID:6927468

Ballou, J E; Gies, R A; Case, A C; Haggard, D L; Buschbom, R L; Ryan, J L

Little information exists on the metabolism and potential health effects of /sup 233/U and /sup 232/U, high-specific-activity U isotopes associated with Th breeder systems. This paper describes the distribution and retention of the two isotopes following inhalation of uranyl nitrate, a simulated process solution. The lungs of rats exposed to /sup 233/UO/sub 2/(NO/sub 3/)/sub 2/ and /sup 232/UO/sub 2/(NO/sub 3/)/sub 2/ aerosols contained from 7 to 23% of the total amount of U retained in the rat after a 30-min inhalation exposure. Uranium was translocated rapidly from the lung and was retained mainly in skeleton, kidney and liver. Amounts equivalent to from one-quarter to one-half the initial lung burden (ILB) of U were excreted in urine the first day after inhalation. Radiation dose estimates based on /sup 233/U and /sup 232/U retention kinetics indicate that lung and skeleton would be the target organs for delayed radiation effects.

• Research Organization: Pacific Northwest Lab., Richland, WA
• OSTI ID: 6927468
• Journal Information: Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 6; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BODY
BODY BURDEN
CLEARANCE
DIGESTIVE SYSTEM
DISTRIBUTION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXCRETION
GLANDS
HEAVY NUCLEI
INHALATION
INTAKE
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAMMALS
NITRATES
NITROGEN COMPOUNDS
NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RESPIRATORY SYSTEM
RETENTION
RODENTS
SKELETON
TISSUE DISTRIBUTION
URANIUM 232
URANIUM 233
URANIUM COMPOUNDS
URANIUM ISOTOPES
URANYL COMPOUNDS
URANYL NITRATES
VERTEBRATES
YEARS LIVING RADIOISOTOPES