Commentary on the 1978 Kristiansand Conference on Nickel Toxicology
Abstracts of presentations at the 1978 Kristiansand Conference on Nickel Toxicity are presented. Major developments in the study of nickel toxicity are summarized. They include: the demonstration that nickel is an essential trace element; the discovery of the first nickel metalloenzyme; the discovery that ureases are also nickel enzymes; the improvement of analytical methods for the determination of nickel in biological material; the recognition of the need to monitor occupationl exposures to nickel; the observation that nickel carbonyl is a potent teratogen in rats; the finding that internal exposure to nickel by ingestion plays a role in exacerbation of nickel eczema in man; and the observation that intrarenal injection of nickel subsulfide in rats induces marked polycythemia which appears to be mediated by enhanced renal synthesis and/or release of erythropoietin.
- Research Organization:
- Univ. of Connecticut School of Medicine, Farmington
- DOE Contract Number:
- EY-76-S-02-3140
- OSTI ID:
- 6772679
- Journal Information:
- Ann. Clin. Lab. Sci.; (United States), Vol. 8:6
- Country of Publication:
- United States
- Language:
- English
Similar Records
Toxicology and metabolism of nickel compounds. Progress report, December 1, 1978-November 30, 1979. [Hamsters and rats]
Toxicology and metabolism of nickel compounds. Progress report, December 1, 1975--November 30, 1976. [Tests made with rats and hamsters]
Related Subjects
NICKEL
ABSTRACTS
TOXICITY
BIOLOGICAL MATERIALS
BLOOD
CARBONYLS
ECZEMA
ENZYMES
ERYTHROPOIETIN
INGESTION
KIDNEYS
MAN
MEETINGS
MONITORING
NICKEL SULFIDES
OCCUPATIONAL SAFETY
QUANTITATIVE CHEMICAL ANALYSIS
RATS
TERATOGENESIS
TRACE AMOUNTS
UREASE
ANIMALS
BODY
BODY FLUIDS
CHALCOGENIDES
CHEMICAL ANALYSIS
DISEASES
DOCUMENT TYPES
ELEMENTS
HYDROLASES
INTAKE
MAMMALS
MATERIALS
METALS
NICKEL COMPOUNDS
ORGANS
PRIMATES
RODENTS
SAFETY
SKIN DISEASES
SULFIDES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)