Toxicology and metabolism of nickel compounds. Progress report, December 1, 1978-November 30, 1979. [Hamsters and rats]

Technical Report · Wed Aug 15 04:00:00 EDT 1979

DOI:https://doi.org/10.2172/5787736· OSTI ID:5787736

Sunderman, Jr., F. W.

The toxicology and metabolism of nickel compounds were investigated in rats and hamsters. The new knowledge includes; demonstration that nickel carbonyl is teratogenic for hamsters; elucidation of physiological factors which influence ..cap alpha..Ni/sub 3/S/sub 2/-induced erythrocytosis in rats; development of a sensitive assay for heme oxygenase activity in renal microsomes for use in studies of renal effects of nickel compounds; demonstration that administration of Ni(CO)/sub 4/ to rats inhibits incorporation of /sup 3/H-thymidine into DNA during hepatic regeneration; demonstration that clones of Syrian hamster fetal cells which have been transformed by in vitro exposure to ..cap alpha..Ni/sub 3/S/sub 2/ consistently cause sarcomas following sc injection into nude mice; demonstration that nickel carbonyl-cyclopentadiene dimer induces rhabdomyosarcomas following im injection in rats; observation of differences in carcinogenic activities of several insoluble nickel compounds; discovery that intraocular injection of ..cap alpha..Ni/sub 3/S/sub 2/ induces amelanotic melanomas in rats; and refinement of analytical methods for nickel in biological materials.

• Research Organization: Connecticut Univ., Farmington (USA). School of Medicine
• DOE Contract Number: EY-76-S-02-3140
• OSTI ID: 5787736
• Report Number(s): COO-3140-3
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON COMPOUNDS
CARBONATES
CARCINOGENESIS
CHALCOGENIDES
CHEMICAL ANALYSIS
CHLORIDES
CHLORINE COMPOUNDS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
EYES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
INFORMATION
ISOLATED VALUES
KIDNEYS
LIVER
MALFORMATIONS
MAMMALS
METABOLISM
NICKEL CARBONATES
NICKEL CHLORIDES
NICKEL COMPOUNDS
NICKEL SELENIDES
NICKEL SULFIDES
NUMERICAL DATA
ORGANS
OXYGEN COMPOUNDS
PATHOGENESIS
PATHOLOGICAL CHANGES
POWDERS
RATS
RODENTS
SELENIDES
SELENIUM COMPOUNDS
SENSE ORGANS
SULFIDES
SULFUR COMPOUNDS
TERATOGENESIS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES