Effect of low pH on thermotolerance induction using fractionated 45/sup 0/C hyperthermia

Journal Article · Sun Mar 01 04:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575418· OSTI ID:6770574

Goldin, E M; Leeper, D B

The effect of low pH on thermotolerance induction was studied in Chinese hamster ovary cells in culture. An exposure of 10 min at 45/sup 0/C resulted in maximal thermotolerance 7 h later. The thermotolerance ratio (TTR), defined as the ratio of the D/sub 0/ of the second (thermotolerant) heat survival curve to the D/sub 0/ of the initial heat survival curve, was found to be 4.2 +- 0.2 for pH 7.2. The pH was reduced during both heating and induction intervals, and the TTR was reduced proportionately with pH to a lowest value of 1.7 at pH 6.3. The D/sub 0/ values for the single-dose heat survival curves fell from 3.6 min at pH 7.2 to 1.3 min at pH 6.3, while those of the thermotolerant heat survival curves fell from 14.8 min at pH 7.2 to 2.4 min at pH 6.3. These data are discussed in light of the potential application of hyperthermia as a treatment modality in tumor therapy.

• Research Organization: Thomas Jefferson Univ., Philadelphia, PA
• OSTI ID: 6770574
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
CELL CULTURES
ENERGY
FEMALE GENITALS
GONADS
HAMSTERS
HEAT
HYPERTHERMIA
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
OVARIES
PH VALUE
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RODENTS
SURVIVAL CURVES
TEMPERATURE DEPENDENCE
THERAPY
TOLERANCE
VERTEBRATES