Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss
This report presents data from 153 healthy, early postmenopausal women who were randomly allocated to two years of treatment with estrogen or placebo. Bone mineral content in the forearms was measured by single-photon absorptiometry, and bone mineral density of the lumbar spine and total-body bone mineral by dual-photon absorptiometry, before and after one and two years of treatment. At the end of the two years, there were highly significant differences of 6 to 7 percent between the estrogen and the placebo groups at all sites measured. The range of the changes of the spine measurement was twice that of the forearm and total-body measurements. It is concluded that measurement of the forearm by single-photon absorptiometry is superior to measurement of the spine by dual-photon absorptiometry both in clinical studies and in the individual patient for detecting estrogen-dependent bone loss and its treatment by estrogen replacement.
- Research Organization:
- Univ. of Copenhagen (Denmark)
- OSTI ID:
- 6770520
- Journal Information:
- Am. J. Med.; (United States), Vol. 84:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Lack of seasonal variation in bone mass and biochemical estimates of bone turnover
Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women
Related Subjects
OSTEOPOROSIS
DIAGNOSIS
SKELETON
EMISSION COMPUTED TOMOGRAPHY
COMPARATIVE EVALUATIONS
ESTRADIOL
GADOLINIUM ISOTOPES
MINERALS
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
WOMEN
ANIMALS
BODY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ESTRANES
ESTROGENS
FEMALES
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RARE EARTH ISOTOPES
SKELETAL DISEASES
STEROID HORMONES
STEROIDS
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics