Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss

Journal Article · Fri Apr 01 04:00:00 EST 1988 · Am. J. Med.; (United States)

DOI:https://doi.org/10.1016/0002-9343(88)90099-X· OSTI ID:6770520

Riis, B J; Christiansen, C

This report presents data from 153 healthy, early postmenopausal women who were randomly allocated to two years of treatment with estrogen or placebo. Bone mineral content in the forearms was measured by single-photon absorptiometry, and bone mineral density of the lumbar spine and total-body bone mineral by dual-photon absorptiometry, before and after one and two years of treatment. At the end of the two years, there were highly significant differences of 6 to 7 percent between the estrogen and the placebo groups at all sites measured. The range of the changes of the spine measurement was twice that of the forearm and total-body measurements. It is concluded that measurement of the forearm by single-photon absorptiometry is superior to measurement of the spine by dual-photon absorptiometry both in clinical studies and in the individual patient for detecting estrogen-dependent bone loss and its treatment by estrogen replacement.

• Research Organization: Univ. of Copenhagen (Denmark)
• OSTI ID: 6770520
• Journal Information: Am. J. Med.; (United States), Journal Name: Am. J. Med.; (United States) Vol. 84:4; ISSN AJMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
ESTRADIOL
ESTRANES
ESTROGENS
FEMALES
GADOLINIUM ISOTOPES
HORMONES
HYDROXY COMPOUNDS
ISOTOPES
MAMMALS
MAN
MINERALS
ORGANIC COMPOUNDS
ORGANS
OSTEOPOROSIS
PATIENTS
PRIMATES
RARE EARTH ISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SKELETAL DISEASES
SKELETON
STEROID HORMONES
STEROIDS
TOMOGRAPHY
VERTEBRATES
WOMEN