Lack of seasonal variation in bone mass and biochemical estimates of bone turnover

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Bone; (United States)

DOI:https://doi.org/10.1016/8756-3282(88)90011-7· OSTI ID:6539664

Overgaard, K; Nilas, L; Johansen, J S; Christiansen, C

Three previous studies have indicated a seasonal variation in bone mineral content, with values during the summer being 1.7% to 7.5% higher than during the winter. We have examined the seasonal influence on both bone mass, biochemical estimates of bone turnover and vitamin D metabolites in 86 healthy women, aged 29-53 years. All participants were followed up for 2 years with examinations every 6 weeks or 3 months. Bone mineral content in the proximal and distal part of the forearm (single photon absorptiometry) did not reveal any significant seasonal variation, whereas bone mineral density of the lumbar spine (dual photon absorptiometry) indicated that the highest values occurred in winter. None of the biochemical parameters showed any statistically significant cyclical changes. Serum concentrations of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D3 showed a highly significant seasonal variation, whereas the serum 1,25-dihydroxyvitamin D concentration was virtually unchanged. We conclude that seasonal variation in bone mineral content and bone turnover should not be taken into account when interpreting data from longitudinal studies of healthy pre- and postmenopausal women on a sufficient vitamin D nutriture.

• Research Organization: Univ. of Copenhagen (Denmark)
• OSTI ID: 6539664
• Journal Information: Bone; (United States), Journal Name: Bone; (United States) Vol. 9:5; ISSN BONED
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARMS
BODY
BODY AREAS
BODY COMPOSITION
COMPUTERIZED TOMOGRAPHY
DENSITY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
FEMALES
LIMBS
MAMMALS
MAN
MENOPAUSE
MINERALS
ORGANS
PHYSICAL PROPERTIES
PRIMATES
SEASONAL VARIATIONS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SKELETON
TOMOGRAPHY
VARIATIONS
VERTEBRAE
VERTEBRATES
VITAMIN D
VITAMINS
WOMEN