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Title: Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage

Abstract

Early-passage skin fibroblasts from different inbred and congenic strains of mice were X-irradiated (1 Gy), and the number of chromatid breaks was determined at 2.0 h after irradiation. The cells from DBA/2N, C3H/HeN, STS/A, C57BL/6N, BALB/cJ, and AKR/N had 25 to 42 chromatid breaks per 100 metaphase cells (efficient repair phenotype). NZB/NJ had greater than 78 and BALB/cAn had 87 to 110 chromatid breaks per 100 cells (inefficient repair phenotype). Differences between BALB/cAn and BALB/c. DBA/2 congenic strains which carry less than 1% of the DBA/2 genome indicate that two genes, one on chromosome 1 linked to bcl-2-Pep-3 and the other on chromosome 4 closely linked to Fv-1, affect the efficiency with which the cells repair radiation-induced chromatin damage.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
National Cancer Institute, Bethesda, MD (USA)
OSTI Identifier:
6769065
Alternate Identifier(s):
OSTI ID: 6769065
Resource Type:
Journal Article
Journal Name:
Genomics; (United States)
Additional Journal Information:
Journal Volume: 2:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMATIN; GENETIC RADIATION EFFECTS; FIBROBLASTS; DNA REPAIR; STRAND BREAKS; RADIOINDUCTION; GENES; MICE; PHENOTYPE; SKIN; X RADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; IONIZING RADIATIONS; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RECOVERY; REPAIR; RODENTS; SOMATIC CELLS; VERTEBRATES 560120* -- Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Potter, M., Sanford, K.K., Parshad, R., Tarone, R.E., Price, F.M., Mock, B., and Huppi, K. Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage. United States: N. p., 1988. Web. doi:10.1016/0888-7543(88)90010-9.
Potter, M., Sanford, K.K., Parshad, R., Tarone, R.E., Price, F.M., Mock, B., & Huppi, K. Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage. United States. doi:10.1016/0888-7543(88)90010-9.
Potter, M., Sanford, K.K., Parshad, R., Tarone, R.E., Price, F.M., Mock, B., and Huppi, K. Fri . "Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage". United States. doi:10.1016/0888-7543(88)90010-9.
@article{osti_6769065,
title = {Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage},
author = {Potter, M. and Sanford, K.K. and Parshad, R. and Tarone, R.E. and Price, F.M. and Mock, B. and Huppi, K.},
abstractNote = {Early-passage skin fibroblasts from different inbred and congenic strains of mice were X-irradiated (1 Gy), and the number of chromatid breaks was determined at 2.0 h after irradiation. The cells from DBA/2N, C3H/HeN, STS/A, C57BL/6N, BALB/cJ, and AKR/N had 25 to 42 chromatid breaks per 100 metaphase cells (efficient repair phenotype). NZB/NJ had greater than 78 and BALB/cAn had 87 to 110 chromatid breaks per 100 cells (inefficient repair phenotype). Differences between BALB/cAn and BALB/c. DBA/2 congenic strains which carry less than 1% of the DBA/2 genome indicate that two genes, one on chromosome 1 linked to bcl-2-Pep-3 and the other on chromosome 4 closely linked to Fv-1, affect the efficiency with which the cells repair radiation-induced chromatin damage.},
doi = {10.1016/0888-7543(88)90010-9},
journal = {Genomics; (United States)},
number = ,
volume = 2:3,
place = {United States},
year = {1988},
month = {4}
}