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Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage

Journal Article · · Genomics; (United States)
; ; ; ; ; ;

Early-passage skin fibroblasts from different inbred and congenic strains of mice were X-irradiated (1 Gy), and the number of chromatid breaks was determined at 2.0 h after irradiation. The cells from DBA/2N, C3H/HeN, STS/A, C57BL/6N, BALB/cJ, and AKR/N had 25 to 42 chromatid breaks per 100 metaphase cells (efficient repair phenotype). NZB/NJ had greater than 78 and BALB/cAn had 87 to 110 chromatid breaks per 100 cells (inefficient repair phenotype). Differences between BALB/cAn and BALB/c. DBA/2 congenic strains which carry less than 1% of the DBA/2 genome indicate that two genes, one on chromosome 1 linked to bcl-2-Pep-3 and the other on chromosome 4 closely linked to Fv-1, affect the efficiency with which the cells repair radiation-induced chromatin damage.

Research Organization:
National Cancer Institute, Bethesda, MD (USA)
OSTI ID:
6769065
Journal Information:
Genomics; (United States), Journal Name: Genomics; (United States) Vol. 2:3; ISSN GNMCE
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CHROMATIN
CONNECTIVE TISSUE CELLS
DNA REPAIR
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IONIZING RADIATIONS
MAMMALS
MICE
ORGANS
PHENOTYPE
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
RODENTS
SKIN
SOMATIC CELLS
STRAND BREAKS
VERTEBRATES
X RADIATION