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Dissociation of in vitro sensitivities of glucose transport and antilipolysis to insulin in NIDDM

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6767877
; ; ; ; ; ;

It is unclear from previous studies whether qualitative or only quantitative differences exist in insulin action in adipocytes obtained from obese subjects with non-insulin-dependent diabetes mellitus (NIDDM) when compared with equally obese nondiabetic subjects. In addition, the role of changes in insulin binding as a cause of insulin resistance in NIDDM is still controversial. The authors compared the sensitivities of (/sup 14/C)-glucose transport and antilipolysis to insulin and measured (/sup 125/I)-insulin binding in abdominal adipocytes obtained from 45 obese nondiabetic, obese diabetic, and 15 nonobese female southwestern American Indians. Compared with the nonobese group, the sensitivities of glucose transport antilipolysis were reduced in both the obese nondiabetic and obese diabetic groups. Compared with the obese nondiabetic subjects, the ED/sub 50/ for stimulation of glucose transport was higher in the obese patients with NIDDM. In contrast, the ED/sub 50/S for antilipolysis were similar in obese diabetic patients and obese nondiabetic subjects. No differences was found in insulin binding in patients with NIDDM when compared with the equally obese nondiabetic subjects. These data indicate 1) the mechanism of insulin resistance differs in NIDDM and obesity, and 2) the selective loss of insulin sensitivity in NIDDM precludes changes in insulin binding as a cause of insulin resistance in this disorder.

Research Organization:
National Institutes of Health, Phoenix, AZ (USA)
OSTI ID:
6767877
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 253:3; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADIPOSE TISSUE
ALDEHYDES
AMERICAN INDIANS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOCHEMISTRY
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CHEMISTRY
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DIABETES MELLITUS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
FAT CELLS
FEMALES
GLUCOSE
HEXOSES
HORMONES
HUMAN POPULATIONS
IN VITRO
INSULIN
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
MEMBRANE TRANSPORT
METABOLIC DISEASES
MINORITY GROUPS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
PEPTIDE HORMONES
PHYSIOLOGY
POPULATIONS
PRIMATES
RADIOISOTOPES
RADIORECEPTOR ASSAY
SACCHARIDES
SOMATIC CELLS
TISSUES
TRACER TECHNIQUES
VERTEBRATES
WOMEN