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Bone blood flow in the femora of anesthetized and conscious dogs in a chronic preparation, using the radioactive tracer microsphere method

Journal Article · · Clin. Orthop.; (United States)
; ; ;
The radioactive tracer microsphere method is applicable to the study of the hemodynamics of bone. As observed previously by others, areas of predominantly cancellous bone produce higher blood flow measurements than do areas of predominantly cortical bone. Bone containing fatty marrow has lower blood flow rates than does bone containing hematopoietic marrow. Blood flow to the femoral neck was the greatest measured (26.74 +/- 1.95 ml/min/100 gm), while the diaphyseal region was the area with the lowest flow (4.67 +/- 0.46 ml/min/100 gm). There was no significant difference between consecutive measurements using up to five differently labeled radioactive microspheres. This enabled observations of the effects of an experimental procedure on bone blood flow in the same animal. Additionally, there was no statistically significant differences between regional blood flows measured 40 days apart in the same animal. Bone blood flow measurements were slightly lower in anesthetized than in conscious dogs. The RTM method is the one most suitable for the estimation of bone blood flow under either acute or chronic conditions.
Research Organization:
Johns Hopkins University School of Medicine, The Department of Orthopaedic Surgery, Baltimore, Maryland
OSTI ID:
6766165
Journal Information:
Clin. Orthop.; (United States), Journal Name: Clin. Orthop.; (United States) Vol. 170; ISSN CORPA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550801 -- Morphology-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANESTHETICS
ANIMAL TISSUES
ANIMALS
BLOOD FLOW
BODY
BONE MARROW
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COMPARATIVE EVALUATIONS
DOGS
DRUGS
FEMUR
HEMATOPOIETIC SYSTEM
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MICROSPHERES
MORPHOLOGY
ORGANS
RADIOPHARMACEUTICALS
SKELETON
TISSUES
VERTEBRATES