Femoral head blood flow in long-term steroid therapy: study of rabbit model
Journal Article
·
· South. Med. J.; (United States)
Using a rabbit model, previous studies showed steroid-induced hyperlipidemia with subsequent fatty embolization of the subchondral arteries and hypertrophy of the marrow fat cells, followed by elevation of femoral head pressure from the normal level of 25 cm to nearly 60 cm H2O after eight weeks of treatment. This has led us to believe that pressure changes lead to decreased blood flow in the femoral head. In our study of 22 New Zealand white adult rabbits, weighing an average of 4.0 kg, 14 received a weekly dose of 12.45 mg of methylprednisolone (Depo-Medrol), and eight served as control. Femoral head blood flow was established using the radioactive microsphere technique. Control and cortisone-treated rabbits had femoral head blood flow measured 6, 8 and 10 weeks after treatment. The average blood flow in the control femoral heads averaged 0.2039 +/- 0.076 ml/min/gm, with no difference in the left side and the right side. In the treated group, the average blood flow at ten weeks was 0.162 +/- 0.039 ml/min/gm on the right and 0.164 +/- 0.037 ml/min/gm on the left, which was significantly different. This is parallel to unpredictable clinical findings in human beings.
- Research Organization:
- Univ. of Virginia Medical Center, Charlottesville
- OSTI ID:
- 7190473
- Journal Information:
- South. Med. J.; (United States), Journal Name: South. Med. J.; (United States) Vol. 76:12; ISSN SMJOA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Laser Doppler flowmetry for bone blood flow measurement: correlation with microsphere estimates and evaluation of the effect of intracapsular pressure on femoral head blood flow
Effect of the high femoral osteotomy upon the vascularity and blood supply of the hip joint
Evaluation of noncoronary sources of left ventricular perfusion to intercoronary collateral-dependent myocardium due to chronic major vessel occlusion: absent contribution of luminal and extracardiac channels
Journal Article
·
Tue Dec 31 23:00:00 EST 1985
· J. Orthop. Res.; (United States)
·
OSTI ID:5017066
Effect of the high femoral osteotomy upon the vascularity and blood supply of the hip joint
Journal Article
·
Tue May 01 00:00:00 EDT 1984
· Surg. Gynecol. Obstet.; (United States)
·
OSTI ID:6832976
Evaluation of noncoronary sources of left ventricular perfusion to intercoronary collateral-dependent myocardium due to chronic major vessel occlusion: absent contribution of luminal and extracardiac channels
Journal Article
·
Sat Oct 31 23:00:00 EST 1981
· Am. Heart J.; (United States)
·
OSTI ID:5390019
Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CHEMOTHERAPY
COUNTING TECHNIQUES
FEMUR
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
MICROSPHERES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RABBITS
RADIOISOTOPE SCANNING
SKELETON
STEROIDS
THERAPY
TIME DEPENDENCE
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD FLOW
BODY
CHEMOTHERAPY
COUNTING TECHNIQUES
FEMUR
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
MICROSPHERES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RABBITS
RADIOISOTOPE SCANNING
SKELETON
STEROIDS
THERAPY
TIME DEPENDENCE
VERTEBRATES