Parathyroid imaging with thallium-201, activity in parathyroid and other tissue removed surgically

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760518

Gimlette, T M.D.

Parathyroid imaging by the T1-201 thallous chloride and Tc-99m pertechnetate subtraction technique is moderately successful, but its sensitivity is limited by the difficulty in correctly localizing small parathyroid lesions, particularly those of less than 0.5 g. In a series of 35 patients operated upon for primary or secondary hyperparathyroidism, only one parathyroid lesion out of ten less than 0.5 g was correctly localized, while twenty-nine out of thirty-five over 0.5 g were correctly localized. In order to quantify further the limitations of the test, percentage uptake of Tl-201 in parathyroid lesions has been estimated. Doses of 3.7 MBq (100 ..mu..Ci) T1-201 were injected intravenously in 7 patients when the thyroid was exposed at operation before dissection or compromise of the blood supply occurred. Subsequently weighed and histologically confirmed samples of parathyroid, thyroid and skeletal muscle were counted against a standard in a well counter. Samples had been removed at times from 5 to 180 minutes after the injection of T1-201. Parathyroid activity varied from 0.011-0.033%/g (mean 0.018%/g), thyroid from 0.004-0.014%/g (mean 0.009%/g) and skeletal muscle from 0.001-0.004%/g. Activity in the tissues sampled tended to decrease with time after injection. The findings suggest that a parathyroid uptake of some 0.01% of the imaging dose (74 MBq, 2 mCi) defines approximately the lower limit for correct localization by current methods using T1-201.

• Research Organization: Royal Liverpool Hospital, Liverpool
• OSTI ID: 6760518
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BODY AREAS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
DUAL-ISOTOPE SUBTRACTION TECHNIQUE
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMAGES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
NECK
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARATHYROID GLANDS
PATHOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SAMPLING
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
THYROID
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
YEARS LIVING RADIOISOTOPES