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Localization of enlarged parathyroid glands by thallium-201 and technetium-99m subtraction imaging. Gland mass and parathormone levels in primary hyperparathyroidism

Journal Article · · Clin. Nucl. Med.; (United States)
;
Twenty-two patients, all with surgically proven primary hyperparathyroidism, were studied by TI-201 thallous chloride and Tc-99m pertechnetate subtraction imaging. Fifteen parathyroid adenomata and one hyperplastic gland between 0.33 and 14.8 g were correctly localized in 16 patients. Two adenomata and seven hyperplastic or histologically normal parathyroids between 0.1 g and 1.4 g in seven patients were not localized. One patient had a correctly localized 13.0-g adenoma with a nonlocalized 0.3 g hyperplastic parathyroid gland and there were two false positive localizations. Sensitivity was 64% (glands), and 73% (patients). There was only fair correlation with parathormone (PTH) levels, but these were elevated in all but four of the patients with correctly localized parathyroids. The authors conclude that the imaging procedure is useful but its sensitivity is limited by difficulty in localizing correctly small glands, particularly those of less than 0.5 g, which comprised 29% of those excised.
OSTI ID:
5096707
Journal Information:
Clin. Nucl. Med.; (United States), Journal Name: Clin. Nucl. Med.; (United States) Vol. 4; ISSN CNMED
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADENOMAS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD CHEMISTRY
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HEAVY NUCLEI
HORMONES
HOURS LIVING RADIOISOTOPES
HYPERPARATHYROIDISM
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PARATHORMONE
PARATHYROID GLANDS
PATIENTS
PEPTIDE HORMONES
PERTECHNETATES
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
REFRACTORY METAL COMPOUNDS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES