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Limits to parathyroid imaging with thallium-201 confirmed by tissue uptake and phantom studies

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:5094914
; ; ; ;
Correct location by /sup 201/TI imaging of 48 parathyroids in 35 patients was related to size; 25 out of 26 parathyroids of mass greater than 1.0 g were correctly located, none of ten parathyroids less than 0.3 g was correctly located. In seven patients previously imaged, 108 microCi (4.0 MBq) of /sup 201/TI was injected when the thyroid was first exposed surgically. Subsequently weighed and histologically confirmed samples of parathyroid, thyroid, and skeletal muscle were counted against a standard in a well counter. Thallium-201 uptake, as %/g, did not differ between hyperplastic and adenomatous parathyroids. Mean parathyroid uptake was 0.018%/g, thyroid 0.01%/g, muscle 0.0026%/g of administered dose. Lower limits for correct location lay between 0.006-0.0149% of administered dose and between 0.25-0.8 g. Studies using a /sup 201/TI phantom containing small aliquots of 201TI at higher concentrations suggested approximately 0.0075% of the usual patient imaging dose as a lower limit for correct location.
Research Organization:
Royal Liverpool Hospital, England
OSTI ID:
5094914
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 8; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HEAVY NUCLEI
HYPERPARATHYROIDISM
IMAGES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MOCKUP
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PARATHYROID GLANDS
PATIENTS
PHANTOMS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SIZE
STRUCTURAL MODELS
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE