Correlation of nitroaromatic compounds with the mutagenic activity of coal fly ash

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709530963· OSTI ID:6760499

Harris, W R; Remsen, J F; Chess, E K; Later, D W

Stack-collected fly-ash particles from a commercial pulverized-coal power plant were extracted with 60/40 w/w benzene-methanol to remove as much of the organic fraction as possible. The extract was sequentially fractionated on a series of high-performance liquid chromatography columns, and the Salmonella bacterial mutagenicity assay using both normal and nitroreductase-deficient strains was used to localize the most mutagenic fractions. Selected fractions were analyzed by a variety of techniques, including gas chromatography with dual-flame ionization and thermionic nitrogen-phosphorus detectors, gas chromatography-mass spectrometry, direct-probe low-resolution or low-voltage mass spectrometry, and high-resolution mass spectrometry. Mutagenicity data indicated that nitroorganic compounds were the primary mutagens in all samples submitted for chemical analysis. A series of homologous alkylated nitrophenanthrenes appear to be important mutagens in one major fraction, while alkylated nitrofluorenones appear to be the dominant mutagens in a second major fraction. No nitro compounds were identified in a third major fraction. In addition to the nitro compounds, substantial amounts of fluorenones were also found, although these are not believed to contribute to the direct-acting mutagenic activity of the samples.

• Research Organization: Univ. of California, Davis
• OSTI ID: 6760499
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 20:1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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ASHES
BACTERIA
CARBONACEOUS MATERIALS
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FLY ASH
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FOSSIL-FUEL POWER PLANTS
FUELS
MATERIALS
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POWER PLANTS
RESIDUES
SALMONELLA
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THERMAL POWER PLANTS
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