Detection of nitroaromatic compounds on coal combustion particles

Journal Article · Sat Jan 01 04:00:00 EST 1983 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398309530400· OSTI ID:6109368

Hanson, R L; Henderson, T R; Hobbs, C H; Clark, C R; Carpenter, R L; Dutcher, J S; Harvey, T M; Hunt, D F

Mutagenic and nonmutagenic extracts of fly ash from fluidized bed combustion were analyzed to determine the compounds responsible for the direct mutagenic activity (mutagenic activity that does not require added metabolic enzymes in the Salmonella mutagenicity assay). Some nitro derivatives of polycyclic aromatic hydrocarbons which are direct acting mutagens were detected by tandem triple quadrupole mass spectrometry. Treatment of mutagenic and a nonmutagenic extract with excess N/sub 2/O/sub 4/ resulted in 28- and 3200-fold increases, respectively, in direct mutagenicity in Salmonella typhimurium strain TA98 and an increase in the relative abundance of nitroaromatic compounds. Polycyclic aromatic compounds were also detected and tentatively identified by gas chromatography-mass spectrometry. Since, previous studies have shown that polycylic aromatic hydrocarbons may react with NO/sub 2/ to form direct-acting mutagens, it appears that the direct-acting mutag

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 6109368
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 11; ISSN JTEHD
• Country of Publication: United States
• Language: English

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