Metabolism of 1,2,3,4-, 1,2,3,5-, and 1,2,4,5-tetrachlorobenzene in the squirrel monkey

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531076· OSTI ID:6760447

Schwartz, H; Chu, I; Villeneuve, D C; Benoit, F M

The metabolism of three tetrachlorobenzene isomers (TeCB) was investigated in the squirrel monkey. The animals were administered orally 6 single doses of /sup 14/C-labeled 1,2,3,4-, 1,2,4,5-, or 1,2,3,5-tetrachlorobenzene over a 3-wk period at levels ranging from 50 to 100 mg/kg body weight (b.w) and kept in individual metabolism cages to collect urine and feces for radioassay. Approximately 38% (1,2,3,4-TeCB), 36% (1,2,3,5-TeCB), and 18% (1,2,4,5-TeCB) of the doses were excreted respectively in the feces 48 h post administration. In monkeys dosed with 1,2,3,4-TeCB, unchanged compound accounted for 50% of the fecal radioactivity. Unchanged compound accounted for more than 50% of the fecal radioactivity found in the monkeys dosed with 1,2,3,5-TeCB. The fecal metabolites were identified in both groups. No metabolites were detected in the feces of monkeys dosed with 1,2,4,5-TeCB. While the fecal route represented the major route of excretion for 1,2,3,4-TeCB, the other two isomers were eliminated exclusively in the feces. The above data in the squirrel monkey are different from those obtained with the rat and the rabbit, and demonstrate the different metabolic pathways for the isomers.

• Research Organization: Tunney's Pasture, Ottawa, Ontario (Canada)
• OSTI ID: 6760447
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 22:3
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
CHLORINATED AROMATIC HYDROCARBONS
METABOLISM
BIOLOGICAL PATHWAYS
CARBON 14 COMPOUNDS
EXCRETION
FECES
METABOLITES
MONKEYS
ORAL ADMINISTRATION
RADIOASSAY
VARIATIONS
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CLEARANCE
HALOGENATED AROMATIC HYDROCARBONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
VERTEBRATES
WASTES
500200* - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)